Neuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules

Neuronal Pyrophosphatase Catalyzed Entanglement of Phosphate Ions in Posner Molecules
Research paper
Description: 
A recently developed quantum mechanical model of cognition theorizes that neuronal signaling is significantly influenced by entangled Posner molecules (Ca9(PO4)6) in the brain. According to this model, entangled Posner molecules form upon the inorganic pyrophosphatase-mediated hydrolysis of singlet pyrophosphate, which produces two entangled phosphates. These entangled phosphates then coordinate with surrounding Ca2+ and other entangled phosphate molecules to form the S6 symmetric Posner molecule, which is presumed to serve as a qubit for neuronal signaling. This theory assumes that the hydrolysis of pyrophosphate significantly favors singlet pyrophosphate due to its ability to freely rotate while in the binding pocket of pyrophosphatase. However, to our knowledge, this assumption has never been tested. Using molecular dynamics, we were able to conclude that singlet pyrophosphate does not rotate within a timescale of 1 μs while present in the pocket of pyrophosphatase. These results call into question the role of nuclear spin in the specificity of the pyrophosphatase-mediated hydrolysis of pyrophosphate.

Tabs

WHDL ID: 
WHDL-00015208
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